Absence of the cellular prion protein exacerbates and prolongs neuroinflammation in experimental autoimmune encephalomyelitis.

@article{Tsutsui2008AbsenceOT,
  title={Absence of the cellular prion protein exacerbates and prolongs neuroinflammation in experimental autoimmune encephalomyelitis.},
  author={Shigeki Tsutsui and Jennifer Nancy Hahn and Trina A. Johnson and Zenobia Ali and Frank Robert Jirik},
  journal={The American journal of pathology},
  year={2008},
  volume={173 4},
  pages={1029-41}
}
Although the physiological roles of the cellular prion protein (PrP C) remain to be fully elucidated, PrP C has been proposed to represent a potential regulator of cellular immunity. To test this hypothesis, we evaluated the consequences of PrP C deficiency on the course of experimental autoimmune encephalomyelitis induced by immunization with myelin oligodendrocyte glycoprotein peptide. Consistent with augmented proliferative responses and increased cytokine gene expression by myelin… CONTINUE READING

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