Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.

@article{Bergo2002AbsenceOT,
  title={Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.},
  author={Martin O. Bergo and Patricia Ambroziak and Cria O Gregory and Amanda T George and J. C. Otto and Edward Kim and Hiroki Nagase and Patrick J. Casey and Allan Balmain and Stephen G. Young},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 1},
  pages={171-81}
}
After isoprenylation, the Ras proteins and other CAAX proteins undergo two additional enzymatic modifications-endoproteolytic release of the last three amino acids of the protein by the protease Rce1 and methylation of the carboxyl-terminal isoprenylcysteine by the methyltransferase Icmt. This postisoprenylation processing is thought to be important for the association of Ras proteins with membranes. Blocking postisoprenylation processing, by inhibiting Rce1, has been suggested as a potential… CONTINUE READING