Absence of smooth muscle actin-positive pericyte coverage of tumor vessels correlates with hematogenous metastasis and prognosis of colorectal cancer patients.

@article{Yonenaga2005AbsenceOS,
  title={Absence of smooth muscle actin-positive pericyte coverage of tumor vessels correlates with hematogenous metastasis and prognosis of colorectal cancer patients.},
  author={Yoshikuni Yonenaga and Akira Mori and Hisashi Onodera and Seiichi Yasuda and Hideaki Oe and Akihisa Fujimoto and T. Tachibana and Masayuki Imamura},
  journal={Oncology},
  year={2005},
  volume={69 2},
  pages={159-66}
}
OBJECTIVES Immature microvessels, which are not covered by pericytes, are irregular and leaky. We hypothesized that tumor cells can penetrate immature microvessels more easily than mature microvessels. In this study, we investigated the maturation of angiogenesis by the immunohistochemical staining of colorectal cancer specimens and determined the correlation between the microvessel count or the maturity of microvessels and clinicopathological variables. METHODS Ninety-two surgical specimens… CONTINUE READING

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