Absence of significant pharmacokinetic and pharmacodynamic interactions between artemether and quinoline antimalarials

@article{NaBangchang2000AbsenceOS,
  title={Absence of significant pharmacokinetic and pharmacodynamic interactions between artemether and quinoline antimalarials},
  author={Kesara Na-Bangchang and Juntra Karbwang and Ratawan Ubalee and A. Thanavibul and S. Saenglertsilapachai},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2000},
  volume={25},
  pages={171-178}
}
The study was carried out to investigate the pharmacokinetic and pharmacodynamic interactions between artemether (ARTEM) and quinoline antimalarials namely mefloquine (MQ), quinine (QN) and primaquine (PQ) when given concurrently. A randomised comparative, seven way cross-over design was performed in eight healthy male Thais following the administrations of seven drug regimens on seven occasions ie. a single oral dose of ARTEM (300 mg), or MQ (750 mg), or QN (600 mg), or PQ (45 mg) alone, or… CONTINUE READING