Absence of significant germ line p53 mutations in ovarian cancer patients.

@article{Buller1995AbsenceOS,
  title={Absence of significant germ line p53 mutations in ovarian cancer patients.},
  author={Richard E. Buller and Jeffrey S. Skilling and S E Kaliszewski and Tilo Niemann and Barrie Anderson},
  journal={Gynecologic oncology},
  year={1995},
  volume={58 3},
  pages={
          368-74
        }
}
Germ line mutations of the p53 gene have been described in the Li-Fraumeni Cancer Family Syndrome and occur in patients with multifocal gliomas, particularly those with a history of a metachronous cancer or a family history of cancer. p53 dysfunction is often associated with ovarian cancer. Patients with ovarian carcinoma frequently develop synchronous or metachronous cancers and may have a family history of this or related cancers. Thus, we hypothesized that germ line p53 mutations might be… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations