Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients.

@article{Corcoran2002AbsenceOR,
  title={Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients.},
  author={Jonathan P.T. Corcoran and Po Lin So and Malcolm Maden},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 24},
  pages={4735-41}
}
We generated retinoid-deficient adult rats by the removal of retinoids from their diet. We show that their motoneurons undergo neurodegeneration and that there is an accumulation of neurofilaments and an increase in astrocytosis, which is associated with motoneuron disease. These effects are mediated through the retinoic acid receptor alpha. The same receptor deficit is found in motoneurons from patients suffering from spontaneous amyotrophic lateral sclerosis. Furthermore, we show that there… CONTINUE READING
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