Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri

  title={Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri
  author={Michael Graf and Nils Hartmann and Kathrin Reichwald and Christoph Englert},
  journal={Experimental Gerontology},
Nothobranchius furzeri: A Model for Aging Research and More.
Age-dependent decline in fin regenerative capacity in the short-lived fish Nothobranchius furzeri
It is suggested that regenerative processes are initiated earlier and that regeneration overall is more efficient in younger fish than in aged fish.
From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology
It is suggested that Nothobranchius species – and N. furzeri in particular – could become a unique model taxon that bridges interests in ecological and biomedical research and critically evaluates their use as a laboratory model for understanding the evolution of a rapid ageing rate.
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri
It is found that upon aging, Hdac1 is significantly down-regulated in muscle, liver, and brain, and this age-dependent down-regulation in brain clearly correlates with increased mRNA levels of the cyclin-dependent kinase inhibitor cdkn1a (p21).
Influence of Donor Age and Species Longevity on Replicative Cellular Senescence
This literature review concludes that this inverse correlation of proliferative potential and donor age is likely more dependent to developmental stages than to aging per se; i.e. cells taken from a developing organism have higher replicative capacity than cells taking from an adult.
Nontraditional systems in aging research: an update
A plethora of up-to-date findings about studies of aging, longevity, and sometimes even immortality in several valuable but less frequently used systems are discussed, to prove that they offer biogerontologists as much as the more conventional tools.
Aging Triggers H3K27 Trimethylation Hoarding in the Chromatin of Nothobranchius furzeri Skeletal Muscle
Integrated bioinformatics analysis of RNASeq and ChIPSeq revealed a down-modulation of genes involved in cell cycle, differentiation, and DNA repair and an up-regulation of inflammation and senescence genes related to skeletal muscle aging.


Extremely short lifespan in the annual fish Nothobranchius furzeri
The temporal trajectory of survival shows an age-dependent increase in the mortality rate that is typical of organisms with defined lifespans, and N. furzeri could be used as a convenient model for ageing research.
Large Differences in Aging Phenotype between Strains of the Short-Lived Annual Fish Nothobranchius furzeri
New wild-derived lines of the annual fish Nothobranchius furzeri could represent a model system for studying the genetic control of life-history traits in natural populations due to large differences in aging phenotypes in different lines.
Annual fishes of the genus Nothobranchius as a model system for aging research
These fishes can become excellent models for aging studies and can be employed to test the effects of experimental manipulation on aging at a pace comparable with that of Drosophila and to probe the results of natural selection on the evolution of aging‐related genes.
The biology of replicative senescence.
High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research
This work presents a first basis for systematic genomic and genetic analyses aimed at understanding the mechanisms of life span determination in N. furzeri and provides a first insight into its genome and a comparison to medaka, stickleback, tetraodon and zebrafish.
Gender Separation Increases Somatic Growth in Females but Does Not Affect Lifespan in Nothobranchius furzeri
Though female reproductive effort and offspring investment were significantly reduced after separation, as investigated by analysis of clutch size, eggs in the ovaries and ovary mass, the energetic surplus was not reallocated towards somatic maintenance and a significant extension of lifespan could not be observed in either sex.