Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri

@article{Graf2013AbsenceOR,
  title={Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri
},
  author={Michael Graf and Nils Hartmann and Kathrin Reichwald and Christoph Englert},
  journal={Experimental Gerontology},
  year={2013},
  volume={48},
  pages={17-28}
}
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TLDR
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Aging Triggers H3K27 Trimethylation Hoarding in the Chromatin of Nothobranchius furzeri Skeletal Muscle
TLDR
Integrated bioinformatics analysis of RNASeq and ChIPSeq revealed a down-modulation of genes involved in cell cycle, differentiation, and DNA repair and an up-regulation of inflammation and senescence genes related to skeletal muscle aging.
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References

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Extremely short lifespan in the annual fish Nothobranchius furzeri
TLDR
The temporal trajectory of survival shows an age-dependent increase in the mortality rate that is typical of organisms with defined lifespans, and N. furzeri could be used as a convenient model for ageing research.
Large Differences in Aging Phenotype between Strains of the Short-Lived Annual Fish Nothobranchius furzeri
TLDR
New wild-derived lines of the annual fish Nothobranchius furzeri could represent a model system for studying the genetic control of life-history traits in natural populations due to large differences in aging phenotypes in different lines.
Annual fishes of the genus Nothobranchius as a model system for aging research
TLDR
These fishes can become excellent models for aging studies and can be employed to test the effects of experimental manipulation on aging at a pace comparable with that of Drosophila and to probe the results of natural selection on the evolution of aging‐related genes.
The biology of replicative senescence.
High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research
TLDR
This work presents a first basis for systematic genomic and genetic analyses aimed at understanding the mechanisms of life span determination in N. furzeri and provides a first insight into its genome and a comparison to medaka, stickleback, tetraodon and zebrafish.
Gender Separation Increases Somatic Growth in Females but Does Not Affect Lifespan in Nothobranchius furzeri
TLDR
Though female reproductive effort and offspring investment were significantly reduced after separation, as investigated by analysis of clutch size, eggs in the ovaries and ovary mass, the energetic surplus was not reallocated towards somatic maintenance and a significant extension of lifespan could not be observed in either sex.
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