Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri

  title={Absence of replicative senescence in cultured cells from the short-lived killifish Nothobranchius furzeri},
  author={M. Graf and N. Hartmann and K. Reichwald and C. Englert},
  journal={Experimental Gerontology},
  • M. Graf, N. Hartmann, +1 author C. Englert
  • Published 2013
  • Biology, Medicine
  • Experimental Gerontology
  • A major challenge in age research is the absence of short-lived vertebrate model organisms. The turquoise killifish Nothobranchius furzeri has the shortest known lifespan of a vertebrate that can be bred in captivity. The short lived GRZ strain only reaches a maximum age of 3-4 months, whereas other strains (MZM) reach 6-10 months. Most importantly, the short lifespan is associated with typical signs of ageing. To find out more about possible cellular factors that might contribute to the short… CONTINUE READING
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