Absence of ras-gene hot-spot mutations in canine fibrosarcomas and melanomas.

@article{Escobar2004AbsenceOR,
  title={Absence of ras-gene hot-spot mutations in canine fibrosarcomas and melanomas.},
  author={Hugo Murua Escobar and Kathrin G{\"u}nther and Andreas Richter and Jan Thies Soller and Susanne Winkler and Ingo Nolte and Joern Bullerdiek},
  journal={Anticancer research},
  year={2004},
  volume={24 5A},
  pages={3027-8}
}
Point mutations within ras proto-oncogenes, particularly within the mutational hot-spot codons 12, 13 and 61, are frequently detected in human malignancies and in different types of experimentally-induced tumours in animals. So far little is known about ras mutations in naturally occurring canine fibrosarcomas or K-ras mutations in canine melanomas. To… CONTINUE READING