Absence of platelet CD40L identifies patients with X-linked hyper IgM syndrome.

@article{Inwald2000AbsenceOP,
  title={Absence of platelet CD40L identifies patients with X-linked hyper IgM syndrome.},
  author={David Inwald and Marcus J. Peters and Denise Walshe and Allison Jones and E. Graham Davies and Nigel Klein},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={120 3},
  pages={499-502}
}
CD40 ligand (CD40L), a membrane protein expressed on activated T cells, plays a pivotal role in B cell proliferation and differentiation. Mutations in the CD40L gene are associated with a rare immunodeficiency state, X-linked hyper IgM syndrome (XLHIGM). Recently, platelets have been described as capable of expressing CD40L within minutes of stimulation. We have developed a rapid technique to determine expression of CD40L on activated platelets by flow cytometry in whole blood. We have… CONTINUE READING
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