Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

Abstract

Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known that denervation promotes mitochondrial reactive oxygen species (ROS) production in muscle, whereas the initial cause of mitochondrial ROS production… (More)
DOI: 10.1186/s13395-017-0123-0

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Cite this paper

@inproceedings{Karam2017AbsenceOP, title={Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation}, author={Chehade N. Karam and Jianxun Yi and Yajuan Xiao and Kamal R. Dhakal and Lin Zhang and Xuejun Li and Carlo Manno and Jiejia Xu and Kaitao Li and H. Cheng and Jianjie Ma and Jingsong Zhou}, booktitle={Skeletal Muscle}, year={2017} }