Absence of p53 leads to accelerated neointimal hyperplasia after vascular injury.

Abstract

OBJECTIVE It has been suggested that deregulated expression of the tumor suppressor protein p53 may play a role in the pathogenesis of occlusive vascular remodeling. However, the role of p53 in cell proliferation and apoptosis in vascular lesions has been controversial. METHODS AND RESULTS We tested the potential involvement of p53-mediated molecular… (More)

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