Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice.

  title={Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice.},
  author={G Vassileva and Richard J Smeyne and Jim I Morgan},
  journal={Brain research. Molecular brain research},
  volume={46 1-2},
L7/pcp-2 is expressed exclusively in cerebellar Purkinje and retinal bipolar neurons. While the function of L7/pcp-2 is unknown, its mRNA is trafficked into dendrites, suggesting a role in dendritic physiology. To elucidate its function, L7/pcp-2-null mice were generated. These mice are neurologically normal with no signs of cerebellar or retinal dysfunction. The mice are indistinguishable from wild-type littermates with regards to gross neuroanatomy and fine structure of Purkinje cell… CONTINUE READING


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