Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism.

@article{Krausz2000AbsenceOM,
  title={Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism.},
  author={C Krausz and Llu{\'i}s Quintana-Murci and M. Fellous and J P Siffroi and Ken Mcelreavey},
  journal={Molecular human reproduction},
  year={2000},
  volume={6 4},
  pages={298-302}
}
The aetiology of cryptorchidism is for the most part unknown and appears to be multifactorial. Recently, a product of Leydig cells termed Leydig insulin-like hormone (INSL3) has been proposed as a putative trophic hormone of the first part of descent. Absence of Insl3 in male mice results in bilateral cryptorchidism and mutations involving this gene may be a cause of cryptorchidism in man. We sequenced both exons of the human INSL3 gene in 31 men who presented with idiopathic unilateral or… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…