Absence of mouse pleiotrophin does not affect bone formation in vivo.

  title={Absence of mouse pleiotrophin does not affect bone formation in vivo.},
  author={Wolfgang Lehmann and Thorsten Schinke and Arndt F. Schilling and Philip Catal{\'a}-Lehnen and Matthias Gebauer and Pia Pogoda and Louis Charles Gerstenfeld and Johannes R{\"u}ger and Thomas A. Einhorn and Michael Amling},
  volume={35 6},
Pleiotrophin (Ptn) is an extracellular matrix protein that regulates hippocampal synaptic plasticity and learning behavior in vivo. Since the overexpression of Ptn in transgenic mice leads to increased bone formation, we analyzed whether a deficiency in Ptn expression would have a negative effect on bone remodeling. Bones from Ptn-deficient mice and wild-type littermates were analyzed using radiography, muCT imaging and undecalcified histology. Biomechanical stability was determined in a three… CONTINUE READING


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