Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas.

Abstract

We have determined the nucleotide sequences of two independent DNA clones which contained the activated c-myc genes from avian leukosis virus-induced B-cell lymphomas. Neither of these c-myc genes contained missense mutations. This strongly supports the notion that the c-myc proto-oncogene in avian leukosis virus-induced B-cell lymphomas can be oncogenically activated by altered expression of the gene without a change in the primary structure of the gene product.

Cite this paper

@article{Hahn1988AbsenceOM, title={Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas.}, author={Matthias Hahn and William S Hayward}, journal={Molecular and cellular biology}, year={1988}, volume={8 6}, pages={2659-63} }