Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines

@article{Mrel2002AbsenceOM,
  title={Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines},
  author={Philippe M{\'e}rel and Alexandre Prieur and Petra Pfeiffer and Olivier Delattre},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={5654-5659}
}
Structural abnormalities of chromosomes, including translocations and deletions, are extremely frequent in human cancer cells and particularly in breast cancer cells. One hypothesis to account for these alterations is a deficiency in the repair of DNA double-strand breaks (DSB). This repair process relies on two distinct pathways, homologous recombination (HR) and non-homologous DNA end joining (NHEJ). To investigate this latter pathway, we have studied the ability of cell-free extracts from a… CONTINUE READING
15 Citations
9 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Clin

  • KE Rosenzweig, MB Youmell, ST Palayoor, BD. Price
  • Cancer Res., 3, 1149 – 1156.
  • 1997
Highly Influential
6 Excerpts

Biol

  • P Daza, S Reichenberger, +11 authors WH. Lee
  • Chem., 377, 775 – 786.
  • 1996
Highly Influential
2 Excerpts

Nat

  • KK Khanna, Jackson SP.
  • Genet., 27, 247 – 254.
  • 2001

Br

  • JM Davidson, KL Gorringe, +7 authors PA. Edwards
  • J. Cancer, 83, 1309 – 1317.
  • 2000
1 Excerpt

Int

  • RL Loveday, J Greenman, +4 authors MJ. Kerin
  • J. Cancer, 86, 494 – 500.
  • 2000
1 Excerpt

Proc

  • DO Ferguson, JM Sekiguchi, +4 authors FW. Alt
  • Natl. Acad. Sci. USA, 97, 6630 – 6633.
  • 2000
2 Excerpts

Curr

  • ZE Karanjawala, U Grawunder, CL Hsieh, MR. Lieber
  • Biol., 9, 1501 – 1504.
  • 1999
2 Excerpts

Am

  • SA, M Zelada-Hedman, +6 authors FJ. Couch
  • J. Hum. Genet., 62, 676 – 689.
  • 1998

Mol

  • CL Hsieh, Lieber MR.
  • Cell., 1, 347 – 357.
  • 1998

Similar Papers

Loading similar papers…