Absence of linkage disequilibrium at amyloid precursor protein gene locus in Japanese familial Alzheimer's disease with 717Val-->Ile mutation.

Abstract

To date, eleven independent FAD pedigrees with the 717Val-->Ile mutation have been identified. Interestingly, five pedigrees were of Japanese origin and four were of British origin. The apparent ethnic prediction of this mutation raises the possibility that there is a founder effect in these two island nations. We did not observe any significant linkage… (More)

Topics

Cite this paper

@article{Tanaka1993AbsenceOL, title={Absence of linkage disequilibrium at amyloid precursor protein gene locus in Japanese familial Alzheimer's disease with 717Val-->Ile mutation.}, author={H. Tanaka and Satoshi Naruse and Kousuke Seki and Osamu Onodera and H. Kobayashi and Tomohiro Miyatake and Ai Shibata and Yoshimune Sakaki and Kenji Kamino and T. Miki}, journal={Nihon rinsho. Japanese journal of clinical medicine}, year={1993}, volume={51 9}, pages={2452-6} }