Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon.

@article{Habtezion2011AbsenceOK,
  title={Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon.},
  author={Aida Habtezion and D M Toivola and Muhammad Nadeem Asghar and Greg S Kronmal and Jacqueline D Brooks and Eugene C. Butcher and M. Bishr Omary},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 4},
  pages={1445-50}
}
Keratin 8 (K8) is a major intermediate filament protein present in enterocytes and serves an antiapoptotic function in hepatocytes. K8-null mice develop colonic hyperplasia and colitis that are reversed after antibiotic treatment. To investigate the pathways that underlie the mechanism of colonocyte hyperplasia and the normalization of the colonic phenotype in response to antibiotics, we performed genome-wide microarray analysis. Functional annotation of genes that are differentially regulated… CONTINUE READING