Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release.

@article{Saitoe2001AbsenceOJ,
  title={Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release.},
  author={Minoru Saitoe and Thomas L Schwarz and Joy A. Umbach and Cameron B. Gundersen and Yoshiaki Kidokoro},
  journal={Science},
  year={2001},
  volume={293 5529},
  pages={514-7}
}
Little is known about the functional significance of spontaneous miniature synaptic potentials, which are the result of vesicular exocytosis at nerve terminals. Here, by using Drosophila mutants with specific defects in presynaptic function, we found that glutamate receptors clustered normally at neuromuscular junctions of mutants that retained spontaneous transmitter secretion but had lost the ability to release transmitter in response to action potentials. In contrast, receptor clustering was… CONTINUE READING
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