Absence of interleukin-3 does not affect the severity of local and systemic anaphylaxis but does enhance eosinophil infiltration in a mouse model of allergic peritonitis.

@article{Neel2004AbsenceOI,
  title={Absence of interleukin-3 does not affect the severity of local and systemic anaphylaxis but does enhance eosinophil infiltration in a mouse model of allergic peritonitis.},
  author={Nicole F. Neel and Blaine M Creasy and Jennifer N Rankin and Elizabeth M Pierce and Margaret E. McCoy and Rebecca H Daner and Jessica A Fowler and Janet C Daniel and Chris S. Lantz},
  journal={Immunology letters},
  year={2004},
  volume={95 1},
  pages={37-44}
}
Interleukin-3 (IL-3), which is derived from T cells and other sources, can promote the differentiation, proliferation, and migration of mast cells, basophils, and eosinophils. However, little is known about the ability of IL-3 to regulate the function of these cells in IgE-dependent and -independent allergic responses in vivo. Therefore, we sought to investigate the extent to which endogenously produced IL-3 can influence mast cell secretory function, the expression of local and systemic… CONTINUE READING
Highly Cited
This paper has 25 citations. REVIEW CITATIONS