Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis.

@article{Corneth2014AbsenceOI,
  title={Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis.},
  author={Odilia B.J. Corneth and Adriana M. C. Mus and Patrick S. Asmawidjaja and Roel G.J. Klein Wolterink and Menno van Nimwegen and Maarten D. Brem and Yara Hofman and Rudi W Hendriks and Erik Lubberts},
  journal={Arthritis & rheumatology},
  year={2014},
  volume={66 2},
  pages={340-9}
}
OBJECTIVE Interleukin-17A (IL-17A) signals through the IL-17 receptor (IL-17R) A/C heterodimer. IL-17RA serves as a common receptor subunit for several IL-17 cytokine family members. Lack of IL-17RA signaling may therefore have additional effects beyond those of lack of IL-17A alone. The present study was undertaken to determine the role of IL-17RA signaling in autoimmune arthritis. METHODS Disease incidence and severity were scored in type II collagen-treated wild-type, IL-17RA-deficient… CONTINUE READING