Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice

@article{GeorgesLabouesse1996AbsenceOI,
  title={Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice},
  author={Elisabeth Georges-Labouesse and Nadia Messaddeq and Ghassan Yehia and Laurence C. Cadalbert and Andr{\'e}e Di{\'e}rich and Marianne Le Meur},
  journal={Nature Genetics},
  year={1996},
  volume={13},
  pages={370-373}
}
Cell-extracellular matrix interactions have important roles in many biological processes, including embryonic development, growth control and differentiation. Integrins are the principal receptors for extracellular matrix1. They are composed of non-covalently associated α and β chains1. Integrin oc6 can associate with either β1 or β4 (refs 2,3). Both integrin complexes are receptors for laminins, major components of basement membranes2,3. The distribution of α6 (refs 4–10) as well as studies… CONTINUE READING
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