Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes.

@article{Blackmore1991AbsenceOI,
  title={Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes.},
  author={Peter F. Blackmore and Svetlana Mojsov and John H. Exton and Joel Francis Habener},
  journal={FEBS letters},
  year={1991},
  volume={283 1},
  pages={7-10}
}
The effects of glucagon and the glucagon-like peptide GLP-1(7-37) were compared in rat liver hepatocytes. Glucagon elevated cAMP, elevated intracellular free calcium ([Ca2+]i), activated phosphorylase and stimulated gluconeogenesis, whereas GLP-1(7-37) was without effect on any of these parameters. GLP-1(7-37) did not block any of the actions of glucagon. The glucagon analog, des His1[Glu9] glucagon amide, was a partial agonist in liver, but also was an effective antagonist of glucagon actions… CONTINUE READING

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