Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lungs of patients with asthma.

@article{Ollerenshaw1989AbsenceOI,
  title={Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lungs of patients with asthma.},
  author={S L Ollerenshaw and Deborah Jarvis and Ann J. Woolcock and Colin E Sullivan and T Scheibner},
  journal={The New England journal of medicine},
  year={1989},
  volume={320 19},
  pages={1244-8}
}
Vasoactive intestinal polypeptide (VIP) is a neuropeptide present in the nerve fibers of normal lungs, where it acts to relax bronchial smooth muscle. To determine its presence or absence in the lungs of patients with asthma, we examined lung tissue obtained at autopsy or lobectomy from five patients with asthma and nine without asthma. The avidin-biotin-peroxidase complex technique was used to stain tissue for immunoreactivity to VIP. At least 80 tissue sections from each patient were examined… CONTINUE READING

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