Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice.

@article{Liu2005AbsenceOH,
  title={Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice.},
  author={Xiaoli Liu and Jiao Wei and David H. Peng and Matthew D Layne and S F Yet},
  journal={Diabetes},
  year={2005},
  volume={54 3},
  pages={778-84}
}
Increased production of reactive oxygen species contributes to the etiology of diabetes complications. Pathophysiological stimuli that increase oxidative stress upregulate heme oxygenase (HO)-1, a cytoprotective heme-degrading enzyme. We hypothesized that HO-1 may be important in myocardial injury that is exacerbated by diabetes. To test this hypothesis, the left anterior descending coronary arteries of nondiabetic and diabetic wild-type (HO-1(+/+)) and HO-1 null (HO-1(-/-)) mice were ligated… CONTINUE READING