Absence of glutamine isotopic steady state: implications for the assessment of whole-body glutamine production rate.

@article{Acker1998AbsenceOG,
  title={Absence of glutamine isotopic steady state: implications for the assessment of whole-body glutamine production rate.},
  author={Bernadette A C van Acker and Karel W. E. Hulsew{\'e} and Anton J M Wagenmakers and Nicolaas E. P. Deutz and Bernard K. van Kreel and David M. Halliday and Dwight E Matthews and Maarten F. von Meyenfeldt},
  journal={Clinical science},
  year={1998},
  volume={95 3},
  pages={
          339-46
        }
}
1. During infusion of [5-15N]glutamine in patients with gastrointestinal cancer we unexpectedly observed a gradual decrease in time of the appearance rate (Ra) of glutamine in plasma. Here we investigate whether the failure to achieve a plateau isotopic enrichment in plasma is, among other factors, due to incomplete equilibration of the glutamine tracer with the large intramuscular free glutamine pool.2. Plasma and intramuscular glutamine enrichment were measured during 6-11 h infusions of L-[5… CONTINUE READING

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