Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy.

@article{Qu2012AbsenceOG,
  title={Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy.},
  author={Zhen Yu Qu and Gang Liu and Jun Li and Li-Hua Wu and Ying Tan and Xin Zheng and Jie Ao and Ming-Hui Zhao},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2012},
  volume={27 5},
  pages={1931-7}
}
BACKGROUND The renal pathological manifestations of malignancy-associated membranous nephropathy (M-MN) and idiopathic membranous nephropathy (I-MN) are similar. It has been suggested that glomerular IgG4 deposition may play an important role in the pathogenesis of I-MN. In the present study, we compared the IgG subclass of immune complex deposition, clinical data and pathological data of patients with M-MN and I-MN. METHODS Eight patients with M-MN and 42 patients with I-MN diagnosed between… CONTINUE READING
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