Absence of genotoxicity of the carcinogenic sulfated polysaccharides carrageenan and dextran sulfate in mammalian DNA repair and bacterial mutagenicity assays.

@article{Mori1984AbsenceOG,
  title={Absence of genotoxicity of the carcinogenic sulfated polysaccharides carrageenan and dextran sulfate in mammalian DNA repair and bacterial mutagenicity assays.},
  author={Haruyo Mori and Fumiaki Ohbayashi and Iwao Hirono and Tomiko Shimada and Gary M Williams},
  journal={Nutrition and cancer},
  year={1984},
  volume={6 2},
  pages={92-7}
}
The sulfated polysaccharides degraded carrageenan and dextran sulfate sodium were studied for genotoxicity using DNA repair tests employing cultured rat hepatocytes or intestinal mucosal cells. No evidence of unscheduled DNA synthesis was obtained. In addition, both alone and in combination with the comutagen norharman, these substances were nonmutagenic in… CONTINUE READING