Absence of genotoxic effects of the coumarin derivative 4-methylesculetin in vivo and its potential chemoprevention against doxorubicin-induced DNA damage.

@article{Fedato2014AbsenceOG,
  title={Absence of genotoxic effects of the coumarin derivative 4-methylesculetin in vivo and its potential chemoprevention against doxorubicin-induced DNA damage.},
  author={Rafael Palhano Fedato and Edson Luis Maistro},
  journal={Journal of applied toxicology : JAT},
  year={2014},
  volume={34 1},
  pages={
          33-9
        }
}
4-Methylesculetin (4-ME) is a synthetic derivative of coumarin that displays a potent reactive oxygen species (ROS) scavenger and metal chelating agent and therefore has been produced to help reduce the risk of human disease. The main objective of this study was to investigate the in vivo genotoxicity of 4-ME and initially to verify its potential antigenotoxicity on doxorubicin (DXR)-induced DNA damage. Different doses of 4-ME (500, 1000 and 2000 mg kg(-1) body weight) were administered by… CONTINUE READING
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