Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice

Abstract

Changes to the epigenome with aging, and DNA modifications in particular, have been proposed as a central regulator of the aging process, a predictor of mortality, and a contributor to the pathogenesis of age-related diseases. In the central nervous system, control of learning and memory, neurogenesis, and plasticity require changes in cytosine methylation… (More)
DOI: 10.1186/s13072-016-0080-6

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