Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter.

  title={Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter.},
  author={Mark S. Schmidt and Charles Brenner},
  journal={Nature metabolism},
  volume={1 7},

NAD+ metabolism in peripheral neuropathic pain

Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations

This review aims to provide a comprehensive view on NAD+ biology, what causes NAD+ deficits and the journey of NR from its discovery to its clinical development, and to decide which NAD+ precursor could have the best therapeutic potential.

NAD+ Precursors: A Questionable Redundancy

The possibility that the conservation of all of these biosynthetic pathways through evolution occurred because the different NAD+ precursors might serve specialized purposes is discussed.

The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

It is proposed that strategies aimed at raising the levels of NAD+ (e.g., using nicotinamide mononucleotide and Nicotinamide riboside) may be a promising intervention to overcome symptoms of fatigue and to improve the quality of life in patients with ME/CFS.

Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity

Differences in Extracellular NAD+ and NMN Metabolism on the Surface of Vascular Endothelial Cells

It is demonstrated that the extracellular metabolism of NAD+ and NMN is vastly different in the vascular endothelium obtained from different species and locations, which may have implications for strategies to modulate the NAD+ system and may cause difficulties for comparing the results of different reports.

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

There is an urgent unmet need to develop reliable strategies to slow down and delay the ageing process to gain a greater understanding of their potential beneficial effects on brain ageing and health span in humans.

Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?

This review aims at assessing the value of B vitamin supplementation in the treatment of heart failure and finds that B vitamins are of particular interest since they are intimately linked to energy metabolism and HF patients are often B vitamin deficient.

Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging

There is no consensus between researchers on NAD precursors and the aim of this review was to determine and discuss their areas of agreement versus disagreement, to highlight the gaps in research, and to give recommendations for future work.



Slc12a8 is a nicotinamide mononucleotide transporter

A specific NMN transporter is discovered, encoded by the Slc12a8 gene, which regulates NMN uptake and cellular NAD+ levels in vitro and in the mouse intestine in vivo, and demonstrates that Slc 12a8 has a critical role in regulating intestinal NAD+ metabolism.

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

A comprehensive dissection of mammalian NAD biosynthesis is presented, the groundwork to understand regulation of NAD-mediated processes, and the organismal homeostasis of this fundamental molecule is laid.

Accurate measurement of nicotinamide adenine dinucleotide (NAD⁺) with high-performance liquid chromatography.

This methodology provides accurate, reliable, and reproducible results of NAD(+ measurement, which enables us to analyze various pathophysiological changes in NAD(+) levels in vitro and in vivo.

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

It is shown that nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous NR and NMN for NAD+ synthesis, explaining the overlapping metabolic effects observed with the two compounds.

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity‐induced axonal degeneration

  • P. VaurB. Brugg E. Duplus
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2017
It is shown that intracortical administration of NR but not NAD+ reduces brain damage induced by NMDA injection and that axonal protection involves defending intracellular NAD+ homeostasis.

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells*

It is demonstrated that low micromolar concentrations of extracellular NAD+ or NAD+ precursors, nicotinamide mononucleotide (NMN) and NR, can reverse the FK866-induced cell death, this representing a plausible explanation for the failure of NAMPT inhibition as an anti-cancer therapy.

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

The results indicate that the pharmacological inhibition of CD73 enzymatic activity could be considered as a means to potentiate the anti-cancer effects of NAMPT inhibitors.