Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter.

@article{Schmidt2019AbsenceOE,
  title={Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter.},
  author={Mark S. Schmidt and Charles Brenner},
  journal={Nature metabolism},
  year={2019},
  volume={1 7},
  pages={
          660-661
        }
}

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References

SHOWING 1-10 OF 12 REFERENCES

Slc12a8 is a nicotinamide mononucleotide transporter

A specific NMN transporter is discovered, encoded by the Slc12a8 gene, which regulates NMN uptake and cellular NAD+ levels in vitro and in the mouse intestine in vivo, and demonstrates that Slc 12a8 has a critical role in regulating intestinal NAD+ metabolism.

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

A comprehensive dissection of mammalian NAD biosynthesis is presented, the groundwork to understand regulation of NAD-mediated processes, and the organismal homeostasis of this fundamental molecule is laid.

Accurate measurement of nicotinamide adenine dinucleotide (NAD⁺) with high-performance liquid chromatography.

This methodology provides accurate, reliable, and reproducible results of NAD(+ measurement, which enables us to analyze various pathophysiological changes in NAD(+) levels in vitro and in vivo.

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

It is shown that nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous NR and NMN for NAD+ synthesis, explaining the overlapping metabolic effects observed with the two compounds.

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity‐induced axonal degeneration

  • P. VaurB. Brugg E. Duplus
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2017
It is shown that intracortical administration of NR but not NAD+ reduces brain damage induced by NMDA injection and that axonal protection involves defending intracellular NAD+ homeostasis.

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells*

It is demonstrated that low micromolar concentrations of extracellular NAD+ or NAD+ precursors, nicotinamide mononucleotide (NMN) and NR, can reverse the FK866-induced cell death, this representing a plausible explanation for the failure of NAMPT inhibition as an anti-cancer therapy.

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

The results indicate that the pharmacological inhibition of CD73 enzymatic activity could be considered as a means to potentiate the anti-cancer effects of NAMPT inhibitors.