Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells.

@article{LeeRueckert2006AbsenceOE,
  title={Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells.},
  author={Miriam Lee-Rueckert and Riikka Vikstedt and Jari Metso and Christian P Ehnholm and Petri T. Kovanen and Matti S Jauhiainen},
  journal={Journal of lipid research},
  year={2006},
  volume={47 8},
  pages={1725-32}
}
In vitro experiments have demonstrated that exogenous phospholipid transfer protein (PLTP), i.e. purified PLTP added to macrophage cultures, influences ABCA1-mediated cholesterol efflux from macrophages to HDL. To investigate whether PLTP produced by the macrophages (i.e., endogenous PLTP) is also part of this process, we used peritoneal macrophages derived from PLTP-knockout (KO) and wild-type (WT) mice. The macrophages were transformed to foam cells by cholesterol loading, and this resulted… CONTINUE READING