• Biology, Medicine
  • Published in
    The Journal of biological…
    1993

Absence of electron transport (Rho 0 state) restores growth of a manganese-superoxide dismutase-deficient Saccharomyces cerevisiae in hyperoxia. Evidence for electron transport as a major source of superoxide generation in vivo.

@article{Guidot1993AbsenceOE,
  title={Absence of electron transport (Rho 0 state) restores growth of a manganese-superoxide dismutase-deficient Saccharomyces cerevisiae in hyperoxia. Evidence for electron transport as a major source of superoxide generation in vivo.},
  author={Dominique Guidot and Joe M McCord and Richard M. Wright and John E. Repine},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 35},
  pages={
          26699-703
        }
}
To address the possibility that electron transport is a biologically significant source of superoxide anion (O2-.) during exposure to hyperoxia in vivo, we constructed Saccharomyces cerevisiae strains with selective disruptions in the gene encoding the mitochondrial manganese-containing superoxide dismutase (Mn-SOD) and/or genes encoding proteins critical for complexes in electron transport. We hypothesized that complete absence of electron transport would restore growth in hyperoxia to a Mn… CONTINUE READING

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