Absence of direct effect of low-power millimeter-wave radiation at 60.4 GHz on endoplasmic reticulum stress

  title={Absence of direct effect of low-power millimeter-wave radiation at 60.4 GHz on endoplasmic reticulum stress},
  author={Christophe Nicolas Nicolaz and Maxim Zhadobov and Fabienne Desmots and Ronan Sauleau and Daniel Thouroude and Denis Michel and Yves Le Drean},
  journal={Cell Biology and Toxicology},
Millimeter waves (MMW) at frequencies around 60 GHz will be used in the very near future in the emerging local wireless communication systems and the potential health hazards of artificially induced environmental exposures represent a major public concern. The main aim of this study was to investigate the potential effects of low-power MMW radiations on cellular physiology. To this end, the human glial cell line, U-251 MG, was exposed to 60.4 GHz radiation at a power density of 0.14 mW/cm2 and… 

Impact of 60‐GHz millimeter waves and corresponding heat effect on endoplasmic reticulum stress sensor gene expression

Experimental data demonstrated that MMW radiations do not change BIP or ORP150 mRNA basal levels, whatever the cell line, the exposure duration or the IPD level, and experimental controls showed that this inhibition is linked to the thermal effect resulting from the MMW exposure.

Evaluation of the Potential Biological Effects of the 60-GHz Millimeter Waves Upon Human Cells

It was shown that millimeter-wave radiation at 60.42 GHz and with a maximum incident power density of 1 mW/cm2 does not alter cell viability, gene expression, and protein conformation.

Near‐field dosimetry for in vitro exposure of human cells at 60 GHz

It is shown that under the considered exposure conditions, the maximal power density, local SAR, and temperature increments equal 57 mW/cm(2) , 1.4 kW/kg, and 6 °C, respectively, for the radiated power of 425‬mW.

Effects of Long-Term Exposure to 60 GHz Millimeter-Wavelength Radiation on the Genotoxicity and Heat Shock Protein (Hsp) Expression of Cells Derived from Human Eye

Exposure to millimeter-wavelength radiation has no effect on genotoxicity in human eye cells, and the comet assay, used to detect DNA strand breaks, and heat shock protein expression showed no statistically significant effects of exposure.

Effects of Millimeter Waves Radiation on Cell Membrane - A Brief Review

The millimeter waves (MMW) region of the electromagnetic spectrum, extending from 30 to 300 GHz in terms of frequency (corresponding to wavelengths from 10 mm to 1 mm), is officially used in

Exposure System and Dosimetry for In Vitro Studies of Biocompatibility of Pulse-Modulated RF Signals of Ultrahigh Field MRI

Under the considered experimental conditions, exposure to pulse-modulated radiations emulating typical ultrahigh field MRI signals, corresponding to temperature increments below 1 °C, does not trigger any heat shock response in human brain cells.

5G mobile networks and health—a state-of-the-science review of the research into low-level RF fields above 6 GHz

There is no confirmed evidence that low-level RF fields above 6 GHz such as those used by the 5 G network are hazardous to human health, and future experimental studies should improve the experimental design with particular attention to dosimetry and temperature control.

Physiological effects of millimeter-waves on skin and skin cells: an overview of the to-date published studies

The scientific evidence concerning the possible effects of millimeter-waves on humans is insufficient to devise science- based exposure limits and to develop science-based human health policies, and precautionary measures should be considered for the deployment of the 5G.

Untargeted metabolomics unveil alterations of biomembranes permeability in human HaCaT keratinocytes upon 60 GHz millimeter-wave exposure

It is hypothesized that MMW might alter the permeability of cell membranes, as reported elsewhere, following a joint metabolomic and lipidomic workflow to account for a potential effect of millimeter waves on biological tissues.



Low‐power millimeter wave radiations do not alter stress‐sensitive gene expression of chaperone proteins

The main results of this study suggest that low‐power 60 GHz radiation does not modify stress‐sensitive gene expression of chaperone proteins.

Interactions between 60-GHz millimeter waves and artificial biological membranes: dependence on radiation parameters

Due to the increasing interest in millimeter-wave (MMW) applications for wireless communication systems, the investigation of their potential biological effects is of utmost importance. In this

Current state and implications of research on biological effects of millimeter waves: a review of the literature.

General trends in the MMW research area are analyzed, some problems and uncertainties are outlined, tasks for future studies are identified, and possible implications for development of exposure safety criteria and guidelines are discussed.

Numerical and Experimental Millimeter-Wave Dosimetry for In Vitro Experiments

This paper provides extensive dosimetry data for in vitro experiments regarding the biological effects of millimeter waves. Two particular frequency ranges have been considered, which are: (1) the

Transmission electron microscopy study of the effects produced by wide-band low-power millimeter waves on MCF-7 human breast cancer cells in culture.

Transmission electron microscopy analysis revealed several ultrastructural features of the MMW-irradiated cells pertinent to cells subjected to sublethal injury, and the antiproliferative effect of the millimeter radiation was confirmed.

Effect of millimeter waves on cyclophosphamide induced suppression of T cell functions.

MWs are shown to ameliorate the immunosuppressive effects of CPA by augmenting the proliferation of splenocytes, and altering the activation and effector functions of CD4+ T cells.

Mobile phones, heat shock proteins and cancer.

It is proposed that repeated exposure to mobile phone radiation acts as a repetitive stress leading to continuous expression of Hsps in exposed cells and tissues, which in turn affects their normal regulation, and cancer results.

Millimeter wave induced reversible externalization of phosphatidylserine molecules in cells exposed in vitro

The results suggest that certain biological effects induced by MMWs could be initiated by membrane changes in exposed cells.

Effect of millimeter wave irradiation on tumor metastasis

Millimeter waves also increased NK cell activity suppressed by CPA, suggesting that a reduction in tumor metastasis by MMWs is mediated through activation of NK cells.

Millimeter wave propagation: spectrum management implications

The millimeter wave spectrum at 30-300 GHz is of increasing interest to service providers and systems designers because of the wide bandwidths available for carrying communications at this frequency