Absence of detectable PML-RARα fusion transcripts in long-term remission patients after BMT for acute promyelocytic leukemia

  title={Absence of detectable PML-RARα fusion transcripts in long-term remission patients after BMT for acute promyelocytic leukemia},
  author={Jos{\'e} Rom{\'a}n and Carmen Mart{\'i}n and Antonio Torres and Ma Guadalupe Garc{\'i}a Jim{\'e}nez and Pedro Andr{\'e}s and Raja Flores and M. J. de la Torre and Joaquin Susmozas S{\'a}nchez and Josefina Serrano and Mar{\'i}a Falc{\'o}n},
  journal={Bone Marrow Transplantation},
Twenty patients with APL in long-term remission after BMT were analyzed for the presence of the PML-RARα x fusion gene by RT-PCR. Ten patients had undergone autologous BMT (six of them peripheral blood stem cell transplantation) and 10 allogeneic BMT. A total of 60 samples were examined by two different protocols. Of the eight patients studied just before conditioning, five showed PML-RARα transcript prior to transplantation. Three of them were in CR and became PCR negative early post… CONTINUE READING
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Molecular analysis ofreaction predicts relapse in acute promyelocytic leukemia

  • H Fukutani, T Naoe, R Ohno
  • Ann PML - RAR a fusion mRNA detected by reverse…
  • 1995

Persistence oftranscripts in acute promyelocytic leukemia

  • K Tobal, MJ Saunders, MR Grey, Yin JAL
  • Br J Haematol
  • 1995

Absence of reverseoutcome in acute promyelocytic leukemia by RT - PCR

  • E Koller, H Karlic, O Krieger
  • Leuke - transcription - polymerase chain reaction…
  • 1994

; 82 : 1264 – 1269 . study

  • D Diverio, PP Pandolfi, V Rossi, A Biondi
  • Blood
  • 1993

Early detection of minimal term remission

  • G Martinelli, C Remiddi, G Visani
  • Blood
  • 1993

Detection of residual cytic leukemia detected by reverse transcriptase / polymerase leukemia more than 10 years after allogeneic bone marrow chain reaction

  • G Nucifora, RA Larson, JD Rowley
  • Oncogene
  • 1992

Molecular diagnosis reverse transcriptase polymerase chain reaction assay for and monitoring of acute promyelocytic leukemia treated with PML - RAR a fusion mRNA

  • K Levine, A DeBlasio, WH Miller
  • Detection of mini - Marrow Transplant
  • 1990

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