Absence of deafness-associated connexin-26 (GJB2) gene mutations in the Omani population.

@article{imek2001AbsenceOD,
  title={Absence of deafness-associated connexin-26 (GJB2) gene mutations in the Omani population.},
  author={Mehmet Akif Şimşek and Nadia M. Al-Wardy and A. Husain Al-Khayat and Muralitharan Shanmugakonar and Talal Al-Bulushi and Mazin Al-Khabory and S Al-Mujeni and Saada Al-Harthi},
  journal={Human mutation},
  year={2001},
  volume={18 6},
  pages={
          545-6
        }
}
We have investigated the prevalence of mutations in the connexin 26 (GJB2) gene in Omani population using both PCR-RFLP and direct DNA sequencing methods. Two common GJB2 gene mutations (35delG and 167delT) were screened in 280 healthy controls and 95 deaf patients using two different PCR-RFLP methods. To investigate other GJB2 mutations, we have amplified and sequenced DNA from 51 unrelated deaf patients and 17 control subjects. None of the samples studied, either by RFLP or sequencing… CONTINUE READING
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