Absence of cumulus cells during in vitro maturation affects lipid metabolism in bovine oocytes.

@article{Auclair2013AbsenceOC,
  title={Absence of cumulus cells during in vitro maturation affects lipid metabolism in bovine oocytes.},
  author={Sylvain Auclair and Rustem E. Uzbekov and S{\'e}bastien Elis and Laura Sanchez and Igor I. Kireev and Lionel Lardic and Rozenn Dalbies-Tran and Svetlana Uzbekova},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2013},
  volume={304 6},
  pages={
          E599-613
        }
}
Cumulus cells (CC) surround the oocyte and are coupled metabolically through regulation of nutrient intake. CC removal before in vitro maturation (IVM) decreases bovine oocyte developmental competence without affecting nuclear meiotic maturation. The objective was to investigate the influence of CC on oocyte cytoplasmic maturation in relation to energy metabolism. IVM with either cumulus-enclosed (CEO) or -denuded (DO) oocytes was performed in serum-free metabolically optimized medium… 
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87 References

Porcine cumulus cell influences ooplasmic mitochondria-lipid distributions, GSH-ATP contents and calcium release pattern after electro-activation.

Gene expression in human cumulus cells: one approach to oocyte competence.

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It is indicated that sodium pyruvate promotes nuclear maturation of bovine CDOs and that a continuing presence of cumulus cells during maturation is important for subsequent development of zygotes to the blastocyst stage.
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