Absence of crystalluria and estimation of renal parameters after oral and intravenous ofloxacin as compared to placebo in healthy volunteers.


An open placebo-controlled study on eleven healthy male volunteers was carried out to investigate renal tolerance and the possibility of crystalluria after oral and intravenous administration of ofloxacin. Subjects received single doses of 200 and 400 mg ofloxacin orally, 200 mg ofloxacin intravenously, or placebo. Urine was collected in several fractions… (More)


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