Absence of compensatory platelet activation in patients with severe haemophilia, but evidence for a platelet collagen-activation defect.

@article{Grnewald2002AbsenceOC,
  title={Absence of compensatory platelet activation in patients with severe haemophilia, but evidence for a platelet collagen-activation defect.},
  author={Martin Gr{\"u}newald and Annelie Siegemund and Anja Gr{\"u}newald and A Konegen and Mario Koksch and Martin Griesshammer},
  journal={Platelets},
  year={2002},
  volume={13 8},
  pages={451-8}
}
Severe haemophilia is a serious, haemorrhagic disorder of the plasmatic coagulation system. In this study we investigated, whether 'compensatory' activation of the platelet coagulation system occurs in this situation. Platelet function was investigated with aggregation, adhesion and flow cytometric assays. In addition, we performed clot and platelet plug formation tests and determined endogenous thrombin potentials in patients with severe haemophilia A or B; results were compared to those of… CONTINUE READING