Absence of clinically relevant pharmacokinetic interaction between ribavirin and tenofovir in healthy subjects.

@article{Ramanathan2006AbsenceOC,
  title={Absence of clinically relevant pharmacokinetic interaction between ribavirin and tenofovir in healthy subjects.},
  author={Srinivasan Valady Ramanathan and A. S. K. Cheng and Angelique Mittan and Ramin Ebrahimi and Brian P. Kearney},
  journal={Journal of clinical pharmacology},
  year={2006},
  volume={46 5},
  pages={559-66}
}
This was a 36-day, open-label, fixed-sequence, multiple-dose drug interaction study in 23 healthy subjects to evaluate the effects of multiple doses of tenofovir disoproxil fumarate on the single-dose pharmacokinetics of ribavirin. Subjects received a 600-mg once-daily oral dose of ribavirin on days 1 and 22 and 300-mg once-daily oral doses of tenofovir disoproxil fumarate on days 17 through 24. Pharmacokinetic sampling was performed on days 1 through 4 and 22 through 25. Pharmacokinetics of… CONTINUE READING