Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits.

@article{Woronowicz2008AbsenceOC,
  title={Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits.},
  author={Alicja Woronowicz and Hisatsugu Koshimizu and Su-Youne Chang and Niamh X. Cawley and Joanna M. Hill and Ramona Marie Rodriguiz and Daniel T Abebe and Caroline S. Dorfman and Vladimir V. Senatorov and An Zhou and Zhi-Gang Xiong and William C. Wetsel and Yoke Peng Loh},
  journal={Hippocampus},
  year={2008},
  volume={18 10},
  pages={1051-63}
}
Molecules that govern the formation, integrity, and function of the hippocampus remain an important area of investigation. Here we show that absence of the proneuropeptide processing enzyme, carboxypeptidase E (CPE) in CPE knock-out (KO) mice had a profound effect on memory, synaptic physiology, and the cytoarchitecture of the hippocampus in these animals. Adult CPE-KO mice displayed deficits in memory consolidation as revealed by the water-maze, object preference, and social transmission of… CONTINUE READING

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