Absence of bcl-2 expression by activated CD45RO+ T lymphocytes in acute infectious mononucleosis supporting their susceptibility to programmed cell death.

@article{Tamaru1993AbsenceOB,
  title={Absence of bcl-2 expression by activated CD45RO+ T lymphocytes in acute infectious mononucleosis supporting their susceptibility to programmed cell death.},
  author={Yoichi Tamaru and Toshio Miyawaki and Katsumasa Iwai and Takashi Tsuji and R Nibu and Akihiro Yachie and Shoichi Koizumi and Nobuhiro Taniguchi},
  journal={Blood},
  year={1993},
  volume={82 2},
  pages={521-7}
}
bcl-2 proto-oncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death (apoptosis). There is now increasing evidence that regulation of bcl-2 expression is a determinant of life or death in normal lymphocytes. We have recently described that activated (CD45RO+) CD4+ and CD8+ T cells in acute infectious mononucleosis (IM) undergo apoptotic cell death on culturing, indicating an activation-driven cell death of mature T cells. In this work, we examine bcl-2… CONTINUE READING

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