Absence of antibody against human papillomavirus type 16 E6 and E7 in patients with cervical cancer is independent of sequence variations.

@article{Nindl2000AbsenceOA,
  title={Absence of antibody against human papillomavirus type 16 E6 and E7 in patients with cervical cancer is independent of sequence variations.},
  author={Ingo 4 Nindl and Klaus Ulrich Zumbach and Michael Pawlita and Karin Teller and Achim Schneider and Matthias D{\"u}rst},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={181 5},
  pages={1764-7}
}
It is not known whether the lack of antibody response against human papillomavirus (HPV) type 16 E6 and E7 among some cervical cancer patients is due to naturally existing sequence variations. In this study, naturally occurring HPV-16 E6 and E7 variants (including the prototype) were cloned, antigens were expressed by in vitro transcription and translation, and the humoral immune response of 34 HPV-16-positive cervical cancer patients was analyzed by radioimmunoprecipitation assay (RIPA). In… CONTINUE READING