Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam

  title={Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam},
  author={M A Silva and Francisco Silveira Guimar{\~a}es and Frederico Guilherme Graeff and Carlos Alberto Bezerra Tomaz},
  journal={Behavioural Brain Research},

Intraventricular infusion of the histamine H1 receptor antagonist chlorpheniramine improves maze performance and has anxiolytic-like effects in aged hybrid Fischer 344×Brown Norway rats

The findings substantiate that histamine H1-receptive sites are involved in learning and fear-related processes and indicate that hypomnesia and hyperanxiety seen in the course of brain aging may be based, in part, on hyperactivation of the central histaminergic neuron system.

Inhibitory avoidance impairments induced by intra-amygdala propranolol are reversed by glutamate but not glucose.

The ability of glucose to reverse impairments following intra-amygdala injections of morphine but not propranolol may reflect the neurotransmitter system or systems through which glucose exerts its effects.

Enhanced conditioned inhibitory avoidance by a combined extract of Zingiber officinale and Ginkgo biloba

The beneficial effects of Zingicomb on conditioned inhibitory avoidance shows that this phytopharmacon is a potent anxiolytic agent which, additionally, can facilitate performance on a learning task, indicating promising clinical applications.

Functional internal complexity of amygdala: focus on gene activity mapping after behavioral training and drugs of abuse.

The studies on the gene activity markers, confronted with other approaches involving neuroanatomy, physiology, and the lesion method, have revealed novel aspects of the amygdala, especially pointing to functional heterogeneity of this brain region that does not fit very well into contemporarily active debate on serial versus parallel information processing within the amygdala.

Nootropic and anxiolytic activity of saponins of Albizzia lebbeck leaves



Basolateral amygdala lesions block diazepam-induced anterograde amnesia in an inhibitory avoidance task.

Findings indicate that the DZP-induced anterograde amnesia for inhibitory avoidance training is mediated through influences involving the BL amygdala nucleus.

The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates

The psychopharmacology of 5-HT3 receptors.

The potential anxiolytic activity of GR38032F, a 5‐HT3‐receptor antagonist

It is concluded that GR38032F is potentially a very potent anxiolytic agent without sedative, anticonvulsant or hypnotic activity.

Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats.

It is concluded that activation of peripheral 5-HT3 receptors leads to aversive-type behaviors, which may be related to gastrointestinal discomfort or malaise.

The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG.

There was strong evidence that lorazepam had a marked effect on the EEG, increasing power in the 1 Hz to 7 Hz and 13 Hz to 20 Hz wavebands, whilst reducingPower in the 8 Hz to 12 Hz waveband and an impairment of daytime function as assessed by psychometric performance and subjective measures.

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

Direct evidence for the existence of 5-HT3 receptors in rat brain tissue and their distribution is reported, based on high affinity binding of the potent 5- HT3 receptor antagonist 3H-GR65630 to homogenates of rat entorhinal cortex.