Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice

@article{ArikawaHirasawa2002AbsenceOA,
  title={Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice},
  author={Eri Arikawa-Hirasawa and Susana G. Rossi and Richard L. Rotundo and Yoshihiko Yamada},
  journal={Nature Neuroscience},
  year={2002},
  volume={5},
  pages={119-123}
}
The collagen-tailed form of acetylcholinesterase (AChE) is concentrated at the vertebrate neuromuscular junction (NMJ), where it is responsible for rapidly terminating neurotransmission. This unique oligomeric form of AChE, consisting of three tetramers covalently attached to a collagen-like tail, is more highly expressed in innervated regions of skeletal muscle fibers, where it is externalized and attached to the synaptic basal lamina interposed between the nerve terminal and the receptor-rich… CONTINUE READING
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