Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma.

@article{Ulaner2003AbsenceOA,
  title={Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma.},
  author={Gary A Ulaner and H. Lisa Huang and Jesse Otero and Zhiquan Zhao and Leah S Ben-Porat and Jaya M. Satagopan and Richard Greg Gorlick and Paul Meyers and John H. Healey and Andrew G. Huvos and Andrew R Hoffman and Marc Ladanyi},
  journal={Cancer research},
  year={2003},
  volume={63 8},
  pages={1759-63}
}
There are two telomere maintenance mechanisms (TMMs) in human tumors, telomerase activation (TA) and, more rarely, the process termed alternative lengthening of telomeres (ALT). Unlike most carcinomas, sarcomas, including osteosarcomas (OS), have been reported to display TA and ALT in more balanced proportions and, thus, present an opportunity to examine the impact of different TMMs on clinical tumor behavior. We studied OS samples from 62 patients for molecular evidence of TA and ALT. Kaplan… CONTINUE READING