Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes

Abstract

Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T cells was associated with mutations in ZAP-70. Since TCR signaling is required in developmental decisions resulting in mature CD4 (and CD8) T cells, the presence of peripheral CD4+ T cells expressing… (More)

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@article{Gelfand1995AbsenceOZ, title={Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes}, author={Erwin W. Gelfand and Kenneth I. Weinberg and B D Mazer and Theresa A. Kadlecek and Arthur Weiss}, journal={The Journal of Experimental Medicine}, year={1995}, volume={182}, pages={1057 - 1065} }