Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.

@article{Nakajo2000AbsenceOW,
  title={Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.},
  author={Nobushige Nakajo and Satoshi Yoshitome and Jun Iwashita and Mitsuru Iida and Katsuhiro Uto and Shuichi Ueno and Kengo Okamoto and Noriyuiki Sagata},
  journal={Genes & development},
  year={2000},
  volume={14 3},
  pages={
          328-38
        }
}
Meiotic cells undergo two successive divisions without an intervening S phase. However, the mechanism of S-phase omission between the two meiotic divisions is largely unknown. Here we show that Wee1, a universal mitotic inhibitor, is absent in immature (but not mature) Xenopus oocytes, being down-regulated specifically during oogenesis; this down-regulation is most likely due to a translational repression. Even the modest ectopic expression of Wee1 in immature (meiosis I) oocytes can induce… CONTINUE READING

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