Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma

@article{Patard2009AbsenceOV,
  title={Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma},
  author={J J Patard and Nathalie Rioux-Leclercq and Damien Masson and Salim Zerrouki and Florence Jouan and Nicolas Collet and Christ{\'e}le Dubourg and Bernard Lobel and Melvin Denis and Patricia Fergelot},
  journal={British Journal of Cancer},
  year={2009},
  volume={101},
  pages={1417 - 1424}
}
Background:The von Hippel–Lindau gene (VHL) alteration, a common event in sporadic clear-cell renal-cell carcinoma (CCRCC), leads to highly vascularised tumours. Vascular endothelial growth factor (VEGF) is the major factor involved in angiogenesis, but the prognostic significance of both VHL inactivation and VEGF expression remain controversial. The aims of this study were to analyse the relationship between VHL genetic and epigenetic alterations, VHL expression and VEGF tumour or plasma… CONTINUE READING

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