Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells.

@article{Keck2011AbsenceOT,
  title={Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells.},
  author={Simone Keck and Ines M{\"u}ller and Gy{\"o}rgy Fej{\'e}r and Iva Savic and Sandrine Tchaptchet and Peter J. Nielsen and Chris Galanos and Michael Huber and Marina A. Freudenberg},
  journal={Journal of immunology},
  year={2011},
  volume={186 9},
  pages={5478-88}
}
In macrophages, two signaling pathways, dependent on MyD88 or TIR domain-containing adaptor-inducing IFN-β (TRIF) signaling, emanate from the LPS receptor TLR4/MD-2. In this study, we show that in murine bone marrow-derived mast cells (BMMCs), only the MyD88-dependent pathway is activated by LPS. The TRIF signaling branch leading both to NF-κB activation and enhanced proinflammatory cytokine production, as well as to IRF3 activation and subsequent IFN-β production, is absent in LPS-stimulated… CONTINUE READING
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